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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 4, 2009, pp. 636-643
Bioline Code: oc09143
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 4, 2009, pp. 636-643

 en Molecular approaches for eco-epidemiological studies of Paracoccidioides brasiliensis check for this species in other resources
Richini-Pereira, Virgínia Bodelão; Bosco, Sandra de Moraes Gimenes; Theodoro, Raquel Cordeiro; Macoris, Severino Assis da Graça & Bagagli, Eduardo

Abstract

Medical mycology has greatly benefited from the introduction of molecular techniques. New knowledge on molecular genetics has provided both theoretical and practical frameworks, permitting important advances in our understanding of several aspects of pathogenic fungi. Considering Paracoccidioides brasiliensis check for this species in other resources in particular, important eco-epidemiological aspects, such as environmental distribution and new hosts were clarified through molecular approaches. These methodologies also contributed to a better understanding about the genetic variability of this pathogen; thus, P. brasiliensis is now assumed to represent a species complex. The present review focuses on some recent findings about the current taxonomic status of P. brasiliensis, its phylogenetic and speciation processes, as well as on some practical applications for the molecular detection of this pathogen in environmental and clinical materials.

Keywords
Paracoccidioides brasiliensis - eco-epidemiology - PCR

 
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