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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 5, 2009, pp. 683-688
Bioline Code: oc09154
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 5, 2009, pp. 683-688

 en Effect of Solanum nudum check for this species in other resources steroids on uninfected and Plasmodium falciparum check for this species in other resources -infected erythrocytes
López, Mary Luz; Blair, Silvia; Sáez, Jairo & Segura, Cesar

Abstract

Steroids from Solanum nudum check for this species in other resources (SNs) have demonstrated antiplasmodial activity against erythrocytic stages of the Plasmodium falciparum check for this species in other resources strain FCB-2. It is well known that steroids can alter the membrane function of erythrocytes. Thus, we assessed alterations in the membranes of uninfected red blood cells, the parasite invasiveness and the solute-induced lysis of parasitised red blood cells (pRBCs). induced by SNs. We found that most merozoites were unable to invade SN-treated erythrocytes. However, transmission electron microscopy revealed no effect on the morphology of uninfected erythrocytes treated with either SN2 or diosgenone and neither SN induced haemolysis of uninfected erythrocytes. SN2 and SN4 inhibited isosmotic sorbitol and alanine-induced haemolysis of pRBCs. In contrast, diosgenone and SN1 did not inhibit solute-induced haemolysis. The inhibition of solute-induced lysis of parasitised erythrocytes by SN2 and SN4 suggest an action of these SNs on new permeability pathways of pRBCs.

Keywords
erythrocyte - Solanum nudum - Plasmodium falciparum - new permeability pathways - ultrastructure - malaria

 
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