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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 104, No. 8, 2009, pp. 1063-1071
Bioline Code: oc09220
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 104, No. 8, 2009, pp. 1063-1071

 en Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi check for this species in other resources infection
de Oliveira, Gabriel Melo; Masuda, Masako Oya; Rocha, Nazaré N; Schor, Nestor; Hooper, Cléber S; de Araújo-Jorge, Tânia C & Henriques-Pons, Andréa

Abstract

Trypanosoma cruzi check for this species in other resources infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not been addressed thoroughly. Regarding myocarditis induced by the infection, we observed in our previous work that Fas-L-/- mice (gld/gld) have very mild inflammatory infiltration when compared to BALB/c mice. However, all mice from both lineages die in the early acute phase. Therefore, in this work we studied the physiological connection relating arterial pressure, renal function/damage and cardiac insufficiency as causes of death. Our results show that a broader set of dysfunctions that could be classified as a cardio/anaemic/renal syndrome is more likely responsible for cardiac failure and death in both lineages. However, gld/gld mice had very early glomerular deposition of IgM and a more intense renal inflammatory response with reduced renal filtration, which is probably responsible for the premature death in the absence of significant myocarditis in gld/gld.

Keywords
Trypanosoma cruzi - Fas-L - myocarditis - acute kidney injury

 
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