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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 4, 2010, pp. 387-390
Bioline Code: oc10068
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 4, 2010, pp. 387-390

 en Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula ( Schistosoma mansoni check for this species in other resources )
Thornhill, Joyce; Kusel, John; de Oliviera, Fabricia Alvisi; Ribeiro, Fabio; Lima, Symone Fulgêncio; Coelho, Paulo Marcos Zech; McVeigh, Paul & Mattos, Ana Carolina Alves


Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.

Schistosoma mansoni - membrane impermeant Lucifer Yellow - nephridiopore - host/parasite interface - linoleic acid

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