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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 105, No. 8, 2010, pp. 949-956
Bioline Code: oc10164
Full paper language: English
Document type: Review Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 105, No. 8, 2010, pp. 949-956

 en Overlooked post-translational modifications of proteins in Plasmodium falciparum check for this species in other resources : N- and O-glycosylation - A review
de Macedo, Cristiana S.; Schwarz, Ralph T.; Todeschini, Adriane R.; Previato, Jose O. & Mendonça-Previato, Lucia

Abstract

Human malignant malaria is caused by Plasmodium falciparum check for this species in other resources and accounts for almost 900,000 deaths per year, the majority of which are children and pregnant women in developing countries. There has been significant effort to understand the biology of P. falciparum and its interactions with the host. However, these studies are hindered because several aspects of parasite biology remain controversial, such as N- and O-glycosylation. This review describes work that has been done to elucidate protein glycosylation in P. falciparum and it focuses on describing biochemical evidence for N- and O-glycosylation. Although there has been significant work in this field, these aspects of parasite biochemistry need to be explored further.

Keywords
glycoproteins - glycosylation - N-glycan - O-glycan - Plasmodium

 
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