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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 4, 2011, pp. 507-509
Bioline Code: oc11087
Full paper language: English
Document type: Short Communication
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 4, 2011, pp. 507-509

 en Miltefosine induces programmed cell death in Leishmania amazonensis check for this species in other resources promastigotes
Marinho, Fernanda de Aquino; Gonçalves, Keyla Cristiny da Silva; de Oliveira, Selma Soares; de Oliveira, Ana-Carolina de Siqueira Couto; Bellio, Maria; d'Avila-Levy, Claudia Masini; dos Santos, André Luis Souza & Branquinha, Marta Helena


In the current study, we evaluated the mechanism of action of miltefosine, which is the first effective and safe oral treatment for visceral leishmaniasis, in Leishmania amazonensis check for this species in other resources promastigotes. Miltefosine induced a process of programmed cell death, which was determined by the externalization of phosphatidylserine, the incorporation of propidium iodide, cell-cycle arrest at the sub-G0/G1 phase and DNA fragmentation into oligonucleosome-sized fragments. Despite the intrinsic variation that is detected in Leishmania spp, our results indicate that miltefosine causes apoptosis-like death in L. amazonensis promastigote cells using a similar process that is observed in Leishmania donovani check for this species in other resources .

leishmaniasis, chemotherapy, apoptosis

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