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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. s1, 2011, pp. 79-84
Bioline Code: oc11143
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. s1, 2011, pp. 79-84

 en On cytoadhesion of Plasmodium vivax check for this species in other resources : raison d'être?
Costa, Fabio TM; Lopes, Stefanie CP; Ferrer, Mireia; Leite, Juliana A; Martin-Jaular, Lorena; Bernabeu, Maria; Nogueira, Paulo A; Mourão, Maria Paula G; Fernandez-Becerra, Carmen; Lacerda, Marcus VG & del Portillo, Hernando

Abstract

It is generally accepted that Plasmodium vivax check for this species in other resources , the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.

Keywords
Plasmodium vivax, malaria, cytoadherence, severe disease

 
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