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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 89, No. 2, 1994, pp. 213-216
Bioline Code: oc94044
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 89, No. 2, 1994, pp. 213-216

 en Reversibility of Muscle and Heart Lesions in Chronic, Trypanosoma cruzi check for this species in other resources Infected Mice after Late Trypanomicidal Treatment
Segura, MA; De Raspi, Molina & Basombrio, MA

Abstract

The effect of trypanomicidal treatment upon established
histopathological  Trypanosoma  cruzi
  check for this species in other resources
 induced lesions was
studied in Swiss mice. The animals were inoculated with 50
trypomastigotes and infection was allowed to progress without
treatment for 99 days. After this period, the animals were divided
in three groups, treated for 30 days with either placebo,
benznidazole (200 mg/kg/day) or nifurtimox (100 mg/kg/day). These
treatments induced 94 and 100% cure rates respectively as detected
by xenodiagnosis and reduction of antibody levels. Autopsies and
histopathological  studies of heart, urinary bladder and skeletal
muscle performed on day 312 after infection showed almost complete
healing without residual lesions. As long periods were allowed
between infection, treatment and autopsy, the results indicate that
tissue lesions depend, up to advances stages, on the continuous
presence of the parasite.

Keywords
Trypanosoma cruzi - chronic infection - chemotherapy - histopathology

 
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