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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 90, No. 2, 1995, pp. 169-177
Bioline Code: oc95036
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 90, No. 2, 1995, pp. 169-177

 en Extramedullary Hematopoiesis in Murine Schistosomiasis Mansoni
HL Lenzi; JA Lenzi; FC Rosman; M Pelajo-Machado; EM Mota; MS Panasco & DN Oliveira

Abstract

'During Schistosoma mansoni infection, there is morphological
evidence of involvement of various hematopoietic growth
factors, which cause eosinophil, neutrophil, megakaryocytic
and erythroid extramedullary foci in the liver, lymph nodes
and omental and mesenteric milky spots. While the eosinophil
metaplasia in the periphery of hepatic granulomas roughly
reproduced the intensity of the medullary eosinopoiesis, the
neutrophil metaplasia, on the contrary, was more intense
during the period of neutrophil depression in the bone marrow.
This fact suggests that extramedullary hematopoietic foci are
locally regulated, and amplify and/or compensate the systemic
hematopoietic response during the infection.

Keywords
eosinophil - neutrophil - megakaryocyte - hematopoiesis - Schistosoma mansoni - lymph nodes - milky spots

 
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