'During Schistosoma mansoni infection, there is morphological
evidence of involvement of various hematopoietic growth
factors, which cause eosinophil, neutrophil, megakaryocytic
and erythroid extramedullary foci in the liver, lymph nodes
and omental and mesenteric milky spots. While the eosinophil
metaplasia in the periphery of hepatic granulomas roughly
reproduced the intensity of the medullary eosinopoiesis, the
neutrophil metaplasia, on the contrary, was more intense
during the period of neutrophil depression in the bone marrow.
This fact suggests that extramedullary hematopoietic foci are
locally regulated, and amplify and/or compensate the systemic
hematopoietic response during the infection.
