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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 90, No. 2, 1995, pp. 221-227
Bioline Code: oc95045
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 90, No. 2, 1995, pp. 221-227

 en Schistosomiasis Vaccine Development: Approaches and Prospects
NR Bergquist

Abstract

Mounting evidence for acquired immunity to schistosomiasis
in humans supports the case for immunological intervention.  On the 
other hand, apid reinfection poses a threat to younger age groups due 
to the slow maturation of natural resistance. However, rational 
approaches, based on advances in immunology and molecular biology, 
have substantially increased the odds of producing an effective
vaccine.  Since the parasite cannot replicate in the human host and serious
morbidity generally occurs only after a relatively long period of heavy 
worm burden, complete protection against infection is not essential. 
The chances of success would increase if more than one of the various
host/parasite interphases were targeted, for example reducing morbidity 
through decreased worm loads as well as through suppression of egg 
production.

Several promising schistosome antigens have now reached an advanced phase of development and are currently undergoing independent confirmatory testing according to a standardized protocol. A few molecules are being contemplated for scaled-up production but, so far, only one has reached the stage of industrial manufacture and safety testing. Since schistosomiasis cannot realistically be controlled by a single approach, vaccination is envisaged to be implemented in conjunction with other means of control, notably chemotherapy.

Keywords
antigen - cytokine - schistosomiasis - Schistosoma - immunity - protection - resistance - vaccine

 
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