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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 109-114
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Bioline Code: oc97175
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 109-114
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Cytokines In The Modulation Of Eosinophilia
Faccioli, Lucia H.; Vargaftig, B.B.; Medeiros, Alexandra I. & Malheiros, Adriana
Abstract
In this review we discuss our recent results showing interleukin 5
(IL-5) involvement in eosinophil migration and in the maintenance of
eosinophilia in blood, bone marrow, lung and peritoneal cavity, in a
visceral larva migrans syndrome model using guinea-pigs infected with
Toxocara canis. We also describe the sequential release of TNF-alpha and
IL-8 during the course of infection, and the interaction between these
cytokines and IL-5 during infection. Finally we propose a new biological
role for IL-5, at least in our model, as a modulator of IL-8 release and
secretion.
Keywords
eosinophils - helminth Parasites - inflammation - cytokines
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© Copyright 1997 Fundacao Oswaldo Cruz - Fiocruz
Alternative site location: http://memorias.ioc.fiocruz.br
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