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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 141-146
Bioline Code: oc97179
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 141-146

 en Modulation By IL-10 Of Antigen-induced Allergic Responses In Mice
Zuany-Amorim, Claudia; Vargaftig, B. Boris & Pretolani, Marina

Abstract

Over the last few years, we examined the anti-allergic properties of interleukin (IL)-10 in different models of inflammation in the mouse, as well as against IgE-dependent activation of mouse bone marrow-derived mast cells (BMMC). We showed that IL-10, concurrently administered with ovalbumin, inhibited inflammatory cell accumulation in the airways and in the peritoneal cavity of sensitized mice, as well as the accompanying cytokine release. IL-10 also blocked antigen-induced cytokine generation by IgE-stimulated BMMC. Together, these results identify a novel biological property of IL-10, as a cytokine with potent anti-allergic activities.

Keywords
interleukin-10 - eosinophils - mast cells - TNF-alpha - interleukin-5

 
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