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Modulation By IL-10 Of Antigen-induced Allergic Responses In Mice
Zuany-Amorim, Claudia; Vargaftig, B. Boris & Pretolani, Marina
Abstract
Over the last few years, we examined the anti-allergic properties of
interleukin (IL)-10 in different models of inflammation in the mouse, as
well as against IgE-dependent activation of mouse bone marrow-derived mast
cells (BMMC). We showed that IL-10, concurrently administered with
ovalbumin, inhibited inflammatory cell accumulation in the airways and in
the peritoneal cavity of sensitized mice, as well as the accompanying
cytokine release. IL-10 also blocked antigen-induced cytokine generation by
IgE-stimulated BMMC. Together, these results identify a novel biological
property of IL-10, as a cytokine with potent anti-allergic activities.
Keywords
interleukin-10 - eosinophils - mast cells - TNF-alpha - interleukin-5
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