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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 211-214
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Bioline Code: oc97189
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 211-214
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Description Of An In Vivo Model For The Assessment Of Eosinophil Chemoattractants In The Mouse
Teixeira, Mauro M.; Williams, Timothy J. & Hellewell, Paul G.
Abstract
Chemokines (chemoattractant cytokines) induce potent and selective
chemotaxis of leukocyte subsets in vitro. Here, we review briefly
the chemokines shown to induce eosinophil chemotaxis in vitro and
describe a novel model for the study of the ability of chemokines to
stimulate eosinophil migration in vivo. Eosinophils were purified
from the blood of mice over-expressing the IL-5 gene and labelled with
111In. Only the C-C chemokines, eotaxin and MIP-1alpha, but not RANTES,
MCP-1, MCP-3, MCP-4, MIP-1beta, KC and MIP-2, effectively induced the
recruitment of 111In-eosinophils in mouse skin. We suggest that this mouse
model will be useful in assessing the role of endogenously-generated
chemokines in mediating eosinophil migration to sites of allergic
inflammation in vivo.
Keywords
chemokines - eosinophils - eotaxin - recruitment
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© Copyright 1997 Fundacao Oswaldo Cruz - Fiocruz Alternative site location: http://memorias.ioc.fiocruz.br
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