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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 215-218
Bioline Code: oc97190
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 215-218

 en A New Murine Model Of Persistent Lung Eosinophilic Inflammation
Russo, Momtchilo; Mariano, Mario & Jancar, Sonia


We summarize here the main characteristics of a novel model of pulmonary hypersensitivity. Mice were immunized with a subcutaneous implant of a fragment of heat solidified chicken egg white and 14 days later challenged with ovalbumin given either by aerosol or by intratracheal instillation. This procedure induces a persistent eosinophilic lung inflammation, a marked bone marrow eosinophilia, and Th2-type isotypic profile with histopathological findings that resemble human asthma. Further, this model is simple to perform, reproducible in different strains of mice, does not require adjuvants nor multiple boosters. Based on these characteristics we propose it as a suitable murine model of allergic eosinophilic lung inflammation.

asthma - late-phase reaction - eosinophil - mice - eosinophil peroxidase

© Copyright 1997 Fundacao Oswaldo Cruz - Fiocruz
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