|
Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 215-218
|
Bioline Code: oc97190
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 215-218
en |
A New Murine Model Of Persistent Lung Eosinophilic Inflammation
Russo, Momtchilo; Mariano, Mario & Jancar, Sonia
Abstract
We summarize here the main characteristics of a novel model of pulmonary
hypersensitivity. Mice were immunized with a subcutaneous implant of a
fragment of heat solidified chicken egg white and 14 days later challenged
with ovalbumin given either by aerosol or by intratracheal instillation.
This procedure induces a persistent eosinophilic lung inflammation, a
marked bone marrow eosinophilia, and Th2-type isotypic profile with
histopathological findings that resemble human asthma. Further, this model
is simple to perform, reproducible in different strains of mice, does not
require adjuvants nor multiple boosters. Based on these characteristics we
propose it as a suitable murine model of allergic eosinophilic lung
inflammation.
Keywords
asthma - late-phase reaction - eosinophil - mice - eosinophil peroxidase
|
|
© Copyright 1997 Fundacao Oswaldo Cruz - Fiocruz Alternative site location: http://memorias.ioc.fiocruz.br
|
|