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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 92, No. s2, 1997, pp. 237-240
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Bioline Code: oc97195
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 92, No. s2, 1997, pp. 237-240
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Does The Eosinophil Have A Protective Role In Amebiasis?
Lopez-Osuna, Martha; Velazquez, Juan R. & Kretschmer, Roberto R.
Abstract
While normal human eosinophils are destroyed in vitro by virulent
Entamoeba histolytica, notwhistanding the presence of antibodies and
complement, activated eosinophils promptly destroy the parasite although
dying also at the end of the process. To study the possible in vivo
participation of eosinophils in invasive amebiasis, we compared the
induction of experimental amebic abscess of the liver (AAL) in gerbils
(Meriones unguiculatus) previously made eosinophilic through
Toxocara canis antigen injection and in normal control gerbils.
After intraportal inoculation of 105 ameba trophozoites (6 and 24 hr), the
ratio of gerbils with AAL, as well as the number and size of the
microabscesses was comparable in eosinophilic and control gerbils. However,
at 96 hr the number and size of the microabscesses were significanly
smaller (p<0.05) in eosinophilic gerbils. On the other hand the actuarial
AAL survival curve up to 45 days post-amebic inoculation was signficantly
(p<0.05) shifted to the right in controls. These results suggest that
antigen-induced eosinophilia may exert a protective effect against AAL in
gerbils.
Keywords
eosinophilia - Entamoeba histolytica - amebic abscess of the liver - gerbils
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