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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 93, No. 6, 1998, pp. 815-818
Bioline Code: oc98216
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 93, No. 6, 1998, pp. 815-818

 en Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
Tânia Rosária Pereira Freitas; Lucio Ayres Caldas & Moacyr Alcoforado Rebello


Prostaglandins (Pgs) have been shown to inhibit the replication of several DNA and RNA viruses. Here we report the effect of prostaglandin (PgA1) on the multiplication of a positive strand RNA virus, Classical Swine Fever Virus (CSFV) in PK15 cells. PgA1 was found to inhibit the multiplication of CSFV. At a concentration of 5 g/ml, which was nontoxic to the cells, PgA1 inhibitis virus production in 99%. In PgA1 treated cells the size and number of characteristic Classical Swine Fever focus decreased in amount.

Classical Swine Fever Virus - Prostaglandin - PK15 cell - virus replication

© Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz
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