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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 93, No. 6, 1998, pp. 815-818
Bioline Code: oc98216
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 93, No. 6, 1998, pp. 815-818

 en Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
Tânia Rosária Pereira Freitas; Lucio Ayres Caldas & Moacyr Alcoforado Rebello

Abstract

Prostaglandins (Pgs) have been shown to inhibit the replication of several DNA and RNA viruses. Here we report the effect of prostaglandin (PgA1) on the multiplication of a positive strand RNA virus, Classical Swine Fever Virus (CSFV) in PK15 cells. PgA1 was found to inhibit the multiplication of CSFV. At a concentration of 5 g/ml, which was nontoxic to the cells, PgA1 inhibitis virus production in 99%. In PgA1 treated cells the size and number of characteristic Classical Swine Fever focus decreased in amount.

Keywords
Classical Swine Fever Virus - Prostaglandin - PK15 cell - virus replication

 
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