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Brazilian Journal of Oral Sciences
Piracicaba Dental School - UNICAMP
EISSN: 1677-3225
Vol. 5, No. 17, 2006, pp. 1041-1047
Bioline Code: os06021
Full paper language: English
Document type: Research Article
Document available free of charge

Brazilian Journal of Oral Sciences, Vol. 5, No. 17, 2006, pp. 1041-1047

 en The role of metronidazole on the establishment and persistence of oralcandidosis
Veronica Quispe Yujra; Alexandre Prado Scherma; Juliana Campos Junqueira; Antônio Olavo Cardoso Jorge & Rosilene Fernandes Da Rocha


The aim of this study was to study the effects of metronidazole on the establishment of oral candidosis and Candida albicans check for this species in other resources colonization in the oral cavity of rats. Forty-eight male rats, negative for yeasts in the oral cavity, were used in the study. The rats were inoculated with a suspension of Candida albicans and treated with metronidazole or plain water (control group). The rats of the candidosis experimental group were sacrificed 7, 15, or 30 days after inoculation and their tongues were analyzed by light microscopy. Colonization by Candida albicans was evaluated 1, 2, 5 and 7 days after inoculation and progressively at 15-day intervals, with a total of 18 collections. The results demonstrated the development of candidosis on the tongue dorsum was similar between the Control and Metronidazole groups for each sacrifice period. However, the colonization results showed that yeasts were recovered in the Metronidazole group in greater numbers than in the Control group after the 37th day of the experiment (6th collection). According this, the long term metronidazole therapy favored the colonization of C. albicans in the oral cavity of rats.

Candida albicans, candidosis, metronidazole, rats

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