Interstitial Lung Disease in a Patient with Chronic Granulomatous Disease|
Moghtaderi, Mozhgan; Kashef, Sara & Rezaei, Nima
Background: Chronic granulomatous disease (CGD) is an inherited phagocytes defect, characterized by
defects of NADPH-oxidase and inability of bacterial killing, which leads to recurrent life-threatening
infections. Respiratory problems, which are the major cause of morbidity in CGD, usually result from
recurrent severe infections; however, vigorous inflammatory response could also cause respiratory
Case Presentation: Herein, an 11 year-old patient with CGD is presented who suffered from chronic
cough and dyspnea for 7 years. Considering the results of chest X-ray, high-resolution computed
tomography, and pulmonary function test, the diagnosis of interstitial lung disease was made.
Conclusion: Early recognition of manifestations associated with CGD and appropriate treatment could
prevent further complications and reduce morbidity and mortality in this group of patients.
Chronic Granulomatous Disease; Interstitial Lung Disease; Immunodeficiency