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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 23, No. 5, 2013, pp. 551-556
Bioline Code: pe13104
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 23, No. 5, 2013, pp. 551-556

 en Association between Helicobacter pylori check for this species in other resources , cagA, and vacA Status and Clinical Presentation in Iranian Children
Rafeey, Mandana; Ghotaslou, Reza; Milani, Morteza; Farokhi, Nima & Ghojazadeh, Morteza

Abstract


Objective: Seroprevalence of Helicobacter pylori check for this species in other resources infection in Iran exceeds 65% of pediatric population. In this study, we intended to find association between the virulence genes (cagA and vacA) and clinical presentations.
Methods: H. pylori isolates were achieved from the gastric mucosa of children. In each case, the gastric biopsy specimens were cultured and the organisms identified. Detection of different genotypes was carried out by PCR method.
Findings: A total of 106 biopsy specimens were cultured and 33 H. pylori isolates obtained. Among these 33 H. pylori strains 24 (73%) were cagA-positive. Genotypes of vacA s1m2, s1m1, s2m2, and s2m1 were 45.5%, 30.3%, 21.2%, and 3%, respectively. Most female patients were infected with genotype s1m2. The vacA-m1 strains were significantly more common in patients with nodular gastritis. There were no statistical differences between the vacA and cagA genotypes and clinical outcomes.
Conclusion: The frequency of cagA genotype was high. In this study, nodular gastritis was a common finding and was rather significantly associated with m1 allele of vacA.

Keywords
Helicobacter Pylori; CagA Protein; VacA Protein; Peptic Ulcer

 
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