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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 36, No. 1, 2004, pp. 34-37
Bioline Code: ph04009
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 36, No. 1, 2004, pp. 34-37

 en Protective effect of a polyherbal drug, ambrex in ethanol induced gastric mucosal lesions in experimental rats
S. Narayan, R. S. Devi, M. Jainu, K. E. Sabitha, C. S. Shyamala Devi


Objective: To investigate the protective effect of ambrex in ethanol-induced gastric mucosal lesions in rats.
Material and Methods: Ethanol-induced gastric mucosal lesions in male Wistar rats were used to evaluate gastric ulcer protective effect of ambrex (40 mg/kg/day p.o. for 15 days). The response to ambrex was assessed from ulcer index, cell proliferation, histopathological changes and alkaline phosphatase (ALP) activity.
Results: Ambrex pretreatment showed protection against ethanol-induced gastric mucosal damage, a significant reduction in the ulcer index and ALP activity, and an increase in the DNA content.
Conclusion: Ambrex offers protection against ethanol-induced gastric ulcers.

Alcohol, alkaline phosphatase, gastric ulcer.

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