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Protective effect of a polyherbal drug, ambrex in ethanol induced gastric mucosal lesions in experimental rats S. Narayan, R. S. Devi, M. Jainu, K. E. Sabitha, C. S. Shyamala Devi Abstract Objective: To investigate the protective effect of ambrex in ethanol-induced gastric mucosal lesions in rats. Material and Methods: Ethanol-induced gastric mucosal lesions in male Wistar rats were used to evaluate gastric ulcer protective effect of ambrex (40 mg/kg/day p.o. for 15 days). The response to ambrex was assessed from ulcer index, cell proliferation, histopathological changes and alkaline phosphatase (ALP) activity. Results: Ambrex pretreatment showed protection against ethanol-induced gastric mucosal damage, a significant reduction in the ulcer index and ALP activity, and an increase in the DNA content. Conclusion: Ambrex offers protection against ethanol-induced gastric ulcers. Keywords Alcohol, alkaline phosphatase, gastric ulcer.

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