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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 6, No. 1, 2007, pp. 645-651
Bioline Code: pr07003
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 6, No. 1, 2007, pp. 645-651

 en A Comparative Evaluation of the Flow and Compaction Characteristics of α-Cellulose obtained from Waste Paper
Ohwoavworhua, FO; Adelakun, TA & Kunle, OO

Abstract

Purpose: Alpha-cellulose obtained as pulp from fibrous plant materials has found use in the pharmaceutical industry as a disintegrant and direct compression diluent. The aim of this study was to evaluate the suitability of α-cellulose obtained from waste paper as a direct compression excipient.
Method: The flow and compaction characteristics of α-cellulose (ACP) obtained from waste paper, in comparison with Avicel PH 101, using the Kawakita and Heckel models were evaluated.
Result: The results indicate that the flow properties of these materials could not be predicted accurately using the Kawakita model. A comparison of compression behaviour and compactibility of the two powders showed Avicel PH 101 to be a slightly better binder.
Conclusion: It was concluded that ACP material could find use as a potential dry binder and direct compression diluent in tableting as the binding properties were comparable to those of Avicel PH 101.

Keywords
Alpha-cellulose, microcrystalline cellulose, flow and compaction characteristics, direct compression diluent.

 
© Copyright 2007. TJPR Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Alternative site location: http://www.tjpr.org

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