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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 7, No. 1, 2008, pp. 921-927
Bioline Code: pr08008
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 7, No. 1, 2008, pp. 921-927

 en A New Flavanone from Flemingia strobilifera check for this species in other resources (Linn) R. Br. and its Antimicrobial Activity
Madan, S.; Singh, G.N.; Kumar, Y.; Kohli, K.; Singh, R.M.; Mir, S.R. & Ahmad, S.

Abstract

Purpose: To carry out a bioactivity guided fractionation and isolation of the antimicrobial constituent(s) of the roots of Flemingia strobilifera check for this species in other resources against some bacteria and fungi.
Methods: The root of F. strobilifera was extracted with methanol, butanol and dichloromethane. Antimicrobial activity of the extracts was determined against both bacteria and fungi while the isolation and characterization of compounds of the extracts was done by column chromatography,2D spectroscopic studies and spectral data (U.V, I.R, NMR and MS).
Results: Flemingia flavanone check for this species in other resources (8, 3'-diprenyl-5, 7, 4'-trihydroxy flavanone), Genistin (5, 4 'dihydroxy isoflavone 7-O-glucoside) and β - sitosterol-D glucoside were isolated from the extracts. Flemingia flavanone showed significant antimicrobial activity against Gram-positive (S. aureus, S. epidermidis, MRSA), Gram-negative bacteria (Ps. aeruginosa, E. coli) and fungi (C. albicans). Genistin showed moderate activity against Gram-positive, Gram-negative bacteria and fungi.
Conclusions: The isolation and antimicrobial activity of presence of Flemingia flavanone is being reported for the first time.

Keywords
Flemingia strobilifera, Flemingiaflavanone (8, 3'-diprenyl-5, 7, 4'-trihydroxy' flavanone), Genistin (5, 4-dihydroxy isoflavone 7-O-glucoside), MeOH (Methanol), BuOH (Butanol), Antimicrobial activity, MIC (Minimum inhibitory concentration).

 
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