Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 7, No. 4, 2008, pp. 1137-1142
Bioline Code: pr08036
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 7, No. 4, 2008, pp. 1137-1142
© Copyright 2008 - TJPR Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Effects of Cassia occidentalis aqueous leaf extract on biochemical markers of tissue damage in rats|
Nuhu, AA & Aliyu, R
Among the Hausas of Northern Nigeria, it is claimed by local (traditional) healers that the infusion of C. occidentalis leaves is used as a cure for hepatitis. This study was designed to evaluate the possible negative effects of the aqueous extract of this herb on serum total proteins, albumin, bilirubin, alanine amino transferase (ALT), aspartate amino transferase (AST) and alkaline phosphatase (ALP), as part of a larger study undertaken by these authors to ascertain the hepatoprotective potential of the plant extract.
Fresh leaves of C. occidentalis were extracted with water and screened for phytochemical components. The extract was used for the treatment of 18 albino rats. Serum from these animals was used for the determination of the test parameters.
The extract showed hypoproteinaemic effect. ALT, AST and ALP levels were significantly elevated (P< 0.05).
Hypoproteinaemic effects, and increase in ALT, AST and ALP are indications that the crude extract of C. occidentalis leaves may be slightly toxic as a concoction for liver ailments.
C. occidentalis, Liver, Serum proteins, Transaminases, Hypoproteinaemic effects
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