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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 8, No. 1, 2009, pp. 53-61
Bioline Code: pr09008
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 8, No. 1, 2009, pp. 53-61

 en The effect of chitosan molecular weight on the properties of alginate/ chitosan microparticles containing prednisolone
Honary, Soheila; Maleki, Maryam & Karami, M

Abstract

Purpose: The aim of the present study was to investigate the effect of chitosan molecular weight on size, size distribution, release rate, mucoadhesive properties and electrostatic bonding of alginate/chitosan microparticles containing prednisolone
Methods: Three mucoadhesive alginate/chitosan microparticle formulations, f1, f2 and f3, were prepared using low, medium and high chitosan molecular weight (MW) chitosan, respectively, by directly spraying alginate solution into a solution of chitosan and calcium chloride at optimum conditions. Prednisolone was incorporated in the alginate solution prior to spraying. The microparticles were then evaluated for prednisolone content, size, release rate, and mucoadhesive properties using appropriate methods. The formation of electrostatic and hydrogen bonds between chitosan and alginate was assessed by differential scanning calorimetetry (DSC) and Fourier transform infrared (FTIR).
Results: The results indicate that high MW chitosan microparticles were significantly (p<0.05) smaller and more uniform in size, with better mucoadhesive properties and lower release rate than the other formulations. FTIR and DSC studies indicate that stronger hydrogen and electrostatic bonding in the formulation containing high MW chitosan than inthe other formulations
Conclusion: The physicochemical properties of chitosan-alginate microparticles are dependent on the molecular weight of chitosan

Keywords
Chitosan, Microparticle, Alginate, Molecular weight, DSC, FITR.

 
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