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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 8, No. 4, 2009, pp. 311-316
Bioline Code: pr09040
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 8, No. 4, 2009, pp. 311-316

 en In-vivo Kinetics of Silymarin check for this species in other resources (Milk Thistle) on Healthy Male Volunteers
Usman, Muhammad; Ahmad, Mahmood; Madni, Asad Ullah; Akhtar, Naveed; Asghar, Waheed; Akhtar, Muhammad; Atif, M & Qamar-uz-zaman, M

Abstract

Purpose: The study was aimed at evaluating the in vivo kinetics of silymarin tablets, a product with anti-hepatotoxic and free radical scavenging activities.
Methods: Silimarin® (Amson Vaccines & Pharma Pvt Ltd) was used as the test product while another silymarin tablet brand, Silliver® (Abbott Laboratories Pak Ltd) was the reference product. The tablets were administered to healthy male volunteers orally at a dose of 200 mg following an overnight fast according to a randomized cross-over design. Scheduled blood samples were collected, centrifuged and the plasma assayed using a sensitive and validated reversed phase high performance liquid chromatographic (RP-HPLC) method. Various pharmacokinetic parameters were calculated based on the non-compartmental model.
Results: Non-significant difference (p < 0.05) was observed in the area under the curve (AUC) of the two brands with values of 10.8 ± 0.4 µg h/ml and 11.2 ± 0.7 µg h/ml, respectively. There was, however, a significant difference (p < 0.05) in the Cmax of the two brands. Other pharmacokinetic parameters evaluated did not show any statistical difference (p < 0.05) between the two products except for mean residence time
Conclusion: The test product can be used as an alternative to the brand, Silliver®-Abbot (reference), only in conditions where maximum plasma concentration (Cmax) is not an important consideration.

Keywords
In vivo kinetics, Silymarin, Milk thistle, RP-HPLC, Pharmacokinetics. .

 
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