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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 8, No. 5, 2009, pp. 425-432
Bioline Code: pr09055
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 8, No. 5, 2009, pp. 425-432

 en Effect of Hydroxypropyl Methylcellulose and Ethyl Cellulose Content on Release Profile and Kinetics of Diltiazem HCl from Matrices
Enayatifard, R.; Saeedi, M.; Akbari, J. & Tabatabaee, Y. Haeri

Abstract


Purpose: To develop a oral controlled matrix drug delivery system for a highly water soluble drug, diltiazem HCl, and investigate its drug release mechanism.
Method: Diltiazem HCl was chosen because of its high water solubility. Tablets containing the drug were prepared by direct compression method using different matrix ratios of ethyl cellulose (EC) and hydroxypropyl methylcellulose (HPMC). The formulations were evaluated in vitro for their dissolution characteristics over a period of 8 h. Drug release was analysed according to various release kinetic models.
Results: The results showed that these polymers slowed down the release of diltiazem HCl from the matrices. In the presence of EC, increasing the concentration of HPMC decreased the release rate of diltiazem. Furthermore, incorporation of EC in tablets with HPMC as the matrix was found to control drug release. Kinetic analysis showed that drug release from three of the formulations was adequately described by zero order model.
Conclusion: The formulations developed could potentially be used for controlled delivery of highly soluble drugs such as diltiazem HCl.

Keywords
Matrix tablets; Diltiazem HCl; Hydroxypropyl methylcellulose; Ethylcellulose; Drug release

 
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