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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 10, No. 2, 2011, pp. 169-176
Bioline Code: pr11024
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 10, No. 2, 2011, pp. 169-176

 en Effect of the Aqueous Extract of Gloriosa superba check for this species in other resources Linn (Langli) Roots on Reproductive System and Cardiovascular Parameters in Female Rats
Malpani, Arati A; Aswar, Urmila M; Kushwaha, Shiv K; Zambare, GN & Bodhankar, SL

Abstract

Purpose: Gloriosa superba check for this species in other resources Linn (liliaceae) has been used to induce labor in the traditional Indian system of medicine. The objective of the study was to evaluate the activity of the aqueous extract of Gloriosa superba (AL) root on the female reproductive system of rat.
Methods: The aqueous extract of Gloriosa superba was prepared by simple maceration. Phytochemical analysis as well as toxicity (in mice) and antifertility studies, uterotrophic assay, duciduoma model, uterotonic assessment in-vitro and in-vivo of aqueous extract was carried out in rats. Oxytocin was used as the uterotonic reference standard. The effect of the extract on cardiovascular parameters was also evaluated.
Results: Phytochemical analysis shows presence of flavonoids, tannins, alkaloids, and glycosides in the aqueous extract of Gloriosa superba. The extract yield was 6 % and was found to be was safe at a dose as high as 550 mg/kg body weight. Antifertility study showed early abortificient activity. No increase in uterus and ducidual weight was observed. Both the reference (oxytocin) and the extract produced dose-dependent contractions but the extract had no effect on heart parameters and blood pressure.
Conclusion: The aqueous extract of Gloriosa superba showed oxytocic activity and early abortifacient activity which may be due to the presence of alkaloids such as colchicine. This provides justification for its use in traditional medicine.

Keywords
Abortificient activity; Blood pressure; Gloriosa superba; Oxytocic activity

 
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