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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 13, No. 1, 2014, pp. 41-46
Bioline Code: pr14006
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 1, 2014, pp. 41-46

 en A Green and Solvent-Free Process for Preparation of High-Purity (–)-Borneol from Leaves of Blumea balsamifera check for this species in other resources (L) DC
Wang, Yuan-Hui; Tian, Hong-Yun; Wang, Ai-Mei; Wang, Hong-Xin & Zou, Chun-Li

Abstract


Purpose: To develop a simple and low cost process for the preparation of high-purity (–)-borneol from leaves of Blumea balsamifera check for this species in other resources (L.) DC..
Methods: An improved hydrodistillation (IHD) equipped with a vertical condenser tube was designed for extracting the volatiles (crude (–)-borneol) without solvent, and comparing with hydrodistillation-solvent extraction (HDSE) and simultaneous distillation and extraction (SDE). The sublimation was used to separated high-purity (–)-borneol. The purities of (–)-borneol products were quantitatively analyzed by gas chromatography (GC), and the (–)-borneol product was analyzed by optical activity and nuclear magnetic resonance (NMR), and the antimicrobial activity was evaluated.
Results: The (–)-borneol content of the volatiles was 82 % in IHD, and much higher than that of HDSE (45 %) and SDE (44 %). After sublimation, the purity of separated (–)-borneol was 92 %, and the recovery was 96 %. The NMR spectral data confirmed that the product was (–)-borneol, and the specific rotation was –36.4° (20 °C, ethanol). Meanwhile, the performances of the (–)-borneol product and standard (–)-borneol were the same in antimicrobial activity.
Conclusion: The work provides a green, efficient and solvent-free process for preparation of high-purity natural (–)-borneol from B. balsamifera leaves.

Keywords
Blumea balsamifera (L.) DC; (–)-Borneol; Green method; Solvent-free distillation

 
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