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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 13, No. 2, 2014, pp. 307-314
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Bioline Code: pr14045
Full paper language: English
Document type: Review Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 13, No. 2, 2014, pp. 307-314
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Prenylation of Aromatic Secondary Metabolites: A New Frontier for Development of Novel Drugs
Alhassan, Alhassan M.; Abdullahi, Musa I.; Uba, Ahmad & Umar, Abdulrashid
Abstract
Prenylation of aromatic secondary metabolites is an important process involved in the biosynthesis of
many biologically active compounds in plants and animals. Many prenylated natural products have been
shown to exhibit very good anti-tumor, anti inflammatory and antimicrobial activities. The addition of
prenyl side chain to an aromatic secondary metabolite often affects its pharmacological activity. The aim
of this review is to examine the influence of the prenyl side chain on the pharmacological activities of
some classes of aromatic secondary metabolites and the potential application of prenylation in the
development of novel drugs
Keywords
Secondary metabolite; Prenylation; Aromatic; Ras antagonist; Novel drugs
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