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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 13, No. 2, 2014, pp. 307-314
Bioline Code: pr14045
Full paper language: English
Document type: Review Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 13, No. 2, 2014, pp. 307-314

 en Prenylation of Aromatic Secondary Metabolites: A New Frontier for Development of Novel Drugs
Alhassan, Alhassan M.; Abdullahi, Musa I.; Uba, Ahmad & Umar, Abdulrashid

Abstract

Prenylation of aromatic secondary metabolites is an important process involved in the biosynthesis of many biologically active compounds in plants and animals. Many prenylated natural products have been shown to exhibit very good anti-tumor, anti inflammatory and antimicrobial activities. The addition of prenyl side chain to an aromatic secondary metabolite often affects its pharmacological activity. The aim of this review is to examine the influence of the prenyl side chain on the pharmacological activities of some classes of aromatic secondary metabolites and the potential application of prenylation in the development of novel drugs

Keywords
Secondary metabolite; Prenylation; Aromatic; Ras antagonist; Novel drugs

 
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