search
for
 About Bioline  All Journals  Testimonials  Membership  News


Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 4, No. 1, 2005, pp. 16-19
Bioline Code: pt05004
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 4, No. 1, 2005, pp. 16-19

 en Evaluation of Antidiabetic Activity of Ginkgo Biloba   check for this species in other resources in Streptozotocin Induced Diabetic Rats
PINAKINI K SHANKAR, VASANTH KUMAR and NAMITA RAO

Abstract

The objective of the study was to evaluate the antidiabetic activity of Ginkgo Biloba   check for this species in other resources and to probe into its mechanism of action.
Methods. Albino wistar rats with streptozotocin induced diabetes were divided into 4 groups of 10 each. Gum acacia, troglitazone 36 mg/kg, Ginkgo biloba 50 mg/kg and 100 mg/kg, were administered to group I (control), group II (standard), group III and group IV respectively. After 10 and 15 days of drug administration fasting blood sugar (FBS), blood glutathione (GSH) and serum ceruloplasmin were estimated.
Results. Ginkgo biloba in a high dose of 100 mg/kg produced a significant reduction in FBS of 31% and increase in blood GSH (57.6%) that is however much less than the fall in FBS produced by troglitazone (47%). However treatment with troglitazone and Ginkgo biloba at both doses did not alter the serum ceruloplasmin levels significantly.
Conclusion. The antidiabetic activity of Ginkgo biloba may be attributed to its antioxidant activity without having a role in metal ion mediated lipid peroxidation.

Keywords
Ginkgo biloba, Antidiabetic, Antioxidant, Troglitazone

 
© Copyright 2005 - Razi Institute for Drug Research (RIDR)
Alternative site location: http://ijpt.iums.ac.ir/

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil