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Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 4, No. 1, 2005, pp. 32-35
Bioline Code: pt05008
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 4, No. 1, 2005, pp. 32-35

 en In Vitro Lipid Peroxidation and Antimicrobial Activity of Mucuna pruriens   check for this species in other resources Seeds
YERRA RAJESHWAR, MALAYA GUPTA and UPAL KANTI MAZUMDER

Abstract

The present investigation is aimed to carry out the in vitro lipid peroxidation and antimicrobial activities of the methanol extract of Mucuna pruriens   check for this species in other resources (MEMP) (Family: Fabaceae) seeds. Lipid peroxidation was monitored by the change in optical density of the prepared concentrations (10-320 μg/ml) and the % inhibition was calculated. Ascorbate/FeSO4-induced peroxidation was inhibited by standard antioxidants such as quercetin, L-ascorbic acid and MEMP. Moreover, the % inhibition of the methanol extract increased with increase in concentration. IC50 value for the MEMP, L-ascorbic acid and quercetin for lipid peroxidation was found to be 217.25 μg/ml, 41 μg/ml and 19.75 μg/ml respectively. The antimicrobial activity of MEMP was determined by disc diffusion method with various Gram positive and Gram-negative microorganisms. MEMP showed broad-spectrum antimicrobial activity against all the tested microorganisms except Staphylococcus aureus   check for this species in other resources ML 152 and Vibrae cholera   check for this species in other resources 14035. The results obtained in the present study indicate that MEMP can be a potential source of natural antioxidant and antimicrobial agent.

Keywords
Mucuna pruriens seeds, In vitro lipid peroxidation, Antimicrobial activity

 
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Alternative site location: http://ijpt.iums.ac.ir/

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