search
for
 About Bioline  All Journals  Testimonials  Membership  News


Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 4, No. 1, 2005, pp. 64-69
Bioline Code: pt05014
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 4, No. 1, 2005, pp. 64-69

 en Hepato Protective and Antioxidant Role of Berberis tinctoria   check for this species in other resources Lesch Leaves on Paracetamol Induced Hepatic Damage in Rats
KANDA SAMY MURUGESH, VEERENDRA CHANNABASAPPA YELIGAR, BHIM CHARAN MAITI and TAPAN KUMAR MAITY

Abstract

The scientific evaluation of medicinal plants used in the preparation of folk remedies has provided modern medicine with effective pharmaceuticals for the treatment of diseases. The methanol extract of Berberis tinctoria   check for this species in other resources Lesch (Berberidaceae) leaves was investigated for its hepatoprotective and antioxidant effects on paracetamol (750 mg/kg) induced acute liver damage in Wistar albino rats. Hepatoprotection activity was measured by using biochemical parameters such as serum glutamate oxalate transaminase and serum Glutamate Pyruvate Transaminase (SGOT and SGPT), alkaline phosphatase (ALP), bilirubin and total protein. The methanol extract of Berberis tinctoria (MEBT) at the doses of (150 mg/kg and 300 mg/Kg) produced significant hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin and lipid peroxidation while it significantly increased the levels of glutathione (GSH), catalyse (CAT) and super oxide dismutase (SOD) in a dose dependant manner. The effects of MEBT were comparable to that of standard drug silymarin. These results suggest that MEBT may have potential therapeutic value in the treatment of some liver disorders, probably by its antioxidative effect on hepatocytes.

Keywords
Berberis tinctoria, Hepatoprotective effect, Antioxidants, Paracetamol

 
© Copyright 2005 - Razi Institute for Drug Research (RIDR)
Alternative site location: http://ijpt.iums.ac.ir/

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil