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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 1, No. 1, 2004, pp. 45-54
Bioline Code: tc04005
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 1, No. 1, 2004, pp. 45-54

 en Research Paper-TOXICITY OF ERYTHROPHLEUM GUINEENSE STEM-BARK: ROLE OF ALKALOIDAL FRACTION
Adeoye, B.A and Oyedapo, O.O

Abstract

The effect of the in vivo administration of the total alkaloidal fractions of the stem-bark of the Erythropleum guineense on certain biological parameters of Sprague-Dawley rats was investigated. The results revealed that plasma alanine aminotransferase activity, liver aspartate aminotransferase activity, liver glycogen, liver protein, creatinine and haemoglobin concentrations were reduced while plasma aspartate aminotransferase activity, liver alanine aminotransferase activity, plasma urea concentration, bilirubin concentration and alkaline phosphatase activity were elevated in Sprague -Dawley rats treated with total alkaloidal fractions of E. guineense stem-bark. The phytochemical assays revealed that the chemical composition of E. guineense include alkaloids, saponins, cardiac glycosides and tannins. The toxicity of the stem-bark of E. guineense could be attributed to the combined toxicity of other constituents such as tannins, saponins and glycosides with the alkaloids as earlier speculated.

Keywords
Toxicity, hepatic, Erythrophelum guineese, alkaloidal fraction, aminotransferases, alkaline phosphatase.

 
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