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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 2, No. 2, 2005, pp. 166-176
Bioline Code: tc05018
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 2, No. 2, 2005, pp. 166-176

 en Research Paper - PHARMACOLOGICAL EVALUATIONS FOR THE RELAXANT EFFECT OF THE HYDROALCOHOLIC EXTRACT OF Tapinanthus dodoneifolius check for this species in other resources ON RAT TRACHEA
OUEDRAOGOMaurice, OUEDRAOGO Sylvin, OUEDRAOGO Lamini, TRAORE Aristide, BELEMTOUGRI G. Raymond, SAWADOGO L. Laya et, GUISSOU, I. Pierre.

Abstract

The present study was designed to investigate the blocking of calcium by the hydroalcoholic extract of Tapinanthus dodoneifolius check for this species in other resources (Tapidod), "in vitro" on rat trachea. To evaluate this effect, the contractile activity of tracheal chains from Wistar Kyoto rats was isometrically recorded. On the isolated tracheal rings the extract produced the following effects: (a) a reduction of the contraction obtained by BaCl2, (b) a bronchorelaxing action, on strips precontracted by KCl, which was not influenced by TEA (3x10-3 M), (c) a concentration-dependent decrease of the spasm evoked by calcium chloride (CaCl2) in K+-rich Ca2+-free physiological salt solution, before and after intracellular calcium depletion (d), an inhibitory effect on contraction induced by acetylcholine in Ca2+-free Krebs-Heinseleit solution supplemented with EDTA (5x10-4M). It is concluded that: 1. The activation of the potassium channels does not play a significant role in the relaxant effect of Tapidod. 2. The antispasmodic property of Tapidod seems to be mediated by the blockade of intracellular Ca2+ release. 3. Most likely an inhibition of the intracellular Ca2+-regulating proteins is involved.

Keywords
Extract of Tapinanthus dodoneifolius (Tapidod); Trachea; Calcium.

 
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