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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 3, No. 4, 2006, pp. 1-12
Bioline Code: tc06047
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 3, No. 4, 2006, pp. 1-12

 en IN VIVO EFFECTS OF CANNABIS SATIVA check for this species in other resources L.EXTRACT ON BLOOD COAGULATION, FAT AND GLUCOSE METABOLISM IN NORMAL AND STREPTOZOCIN-INDUCED DIABETIC RATS
R-A. Levendal and C. L. Frost

Abstract

Cannabis sativa check for this species in other resources is used in indigenous medicine as a treatment for various ailments, including diabetes, and also as an early treatment for snake-bite. In diabetic patients, approximately eighty percent die from a thrombotic death and the development of atherosclerosis is accelerated. This study investigated the effects of Cannabis sativa on normal and streptozocin (STZ)-induced diabetic rats, with the aim of determining its effects on glucose and fat metabolism. The following metabolic changes were observed in Cannabis check for this species in other resources -treated rats: decreased growth rates (normal only), increased liver weights (diabetic only), decreased left rectus femorus muscle mass (normal only), increased total plasma cholesterol levels, increased plasma triglyceride levels (diabetic only), reduced hepatic and skeletal muscle glycogen content (only significant in diabetic hepatic tissue), reduced blood glucose levels (normal group, but not significant).Furthermore, there was a three-fold prolongation in the blood clotting time in the diabetic experimental group relative to the diabetic control group. A similar trend was observed between the control and experimental normal rats. The results indicate that Cannabis sativa increased energy utilization due to a reduction in energy reserves, and has an anticoagulatory effect. However, the mechanisms associated with these effects need to be further investigated.

Keywords
Cannabis sativa, Streptozocin, diabetes mellitus, coagulation

 
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