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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 2, 2007, pp. 219-225
Bioline Code: tc07022
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 2, 2007, pp. 219-225

 en BRINE SHRIMP TOXICITY EVALUATION OF SOME TANZANIAN PLANTS USED TRADITIONALLY FOR THE TREATMENT OF FUNGAL INFECTIONS
Mainen J. Moshi, Carolien J.P. van den Beukel, Omar J.M. Hamza, Zakaria H. Mbwambo, Ramadhani O.S. Nondo, Pax J.Masimba, Mecky I.N. Matee, Modest C.Kapingu, Frans Mikx, Paul E. Verweij, and André J.A.M. van der Ven

Abstract

Plants which are used by traditional healers in Tanzania have been evaluated to obtain preliminary data of their toxicity using the brine shrimps test. The results indicate that 9 out of 44 plant species whose extracts were tested exhibited high toxicity with LC50 values below 20μg/ml. These include Aloe lateritia check for this species in other resources Engl. (Aloaceae) [19.1μg/ml], Cassia abbreviata check for this species in other resources Oliv. (Caesalpiniaceae) [12.7μg/ml], Croton scheffleri check for this species in other resources Pax (Euphorbiaceae) [13.7μg/ml], Hymenodactyon parvifolium check for this species in other resources Brig (Rubiaceae) [13.4μg/ml], Kigelia Africana check for this species in other resources L. (Bignoniaceae) [7.2μg/ml], and Ocimum suave check for this species in other resources Oliv. (Labiatae) [16.7μg/ml]. Twelve plants gave LC50 values between 21 and 50μg/ml, 11 plants gave LC50 values between 50 and 100 μg/ml, and 18 plants gave LC50 values greater than 100 μg/ml.

Keywords
Brine shrimp test; Toxicity evaluation; Traditional antifungal plantsIntroduction

 
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