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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 2, 2007, pp. 165-172
Bioline Code: tc07029
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 2, 2007, pp. 165-172

 en PREVENTION OF RADIATION INDUCED HEMATOLOGICAL ALTERATIONS BY MEDICINAL PLANT ROSMARINUS OFFICINALIS check for this species in other resources , IN MICE
Garima Sancheti and P. K. Goyal

Abstract

The modulatory influence of Rosmarinus officinalis check for this species in other resources (rosemary) leaves extract was investigated in Swiss albino mice at a dose of 3 Gy gamma radiation. For this purpose, adult Swiss albino mice were irradiated with 3 Gy gamma rays in the presence (experimental) or absence (control) of rosemary (1000 mg/kg body wt.). These animals were necropsied and their blood was collected at days 1, 3, 5, 10, 20 and 30 post-irradiation. A decrease in the number of erythrocyte and leucocyte counts, hemoglobin content and hematocrit percentage was scored in the control group; whereas a recovery pattern was recorded in experimental animals and a normal value of hematological parameters were regained by day 30 post-treatment. In irradiated group, glutathione level was registered low in the blood, whereas a significant elevation was estimated in rosemary pre-treated animals. An increase in lipid peroxidation level above normal was evident in serum of irradiated mice, while a significant decrease in such values was noted in rosemary pretreated group. The present study suggests the possible radioprotective ability of rosemary extract.

Keywords
Gamma radiation,Glutathione,Hematology, Lipid peroxidation, Rosmarinus officinalis, Swiss albino mice

 
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