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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 3, 2007, pp. 362-371
Bioline Code: tc07038
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 3, 2007, pp. 362-371

 en ANTIHYPERGLYCEMIC EFFECTS OF SEPARATE AND COMPOSITE EXTRACT OF ROOT OF MUSA PARADISIACA check for this species in other resources AND LEAF OF COCCINIA INDICA check for this species in other resources IN STREPTOZOTOCIN-INDUCED DIABETIC MALE ALBINO RAT.
Mallick, Chhanda; Chatterjee, Kausik; GuhaBiswas, Mehuli & Ghosh, Debidas

Abstract

We evaluated the antihyperglycaemic properties of aqueous-methanolic (40:60) extract of root of Musa paradisiaca check for this species in other resources and leaf of Coccinia indica check for this species in other resources in separate as well as in composite manner by conducting experiment on streptozotocin-induced diabetic rats. We measured food and water intake ability, the fasting blood glucose level, glucose tolerance, activities of important carbohydrate metabolic enzymes like glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, hexokinase in liver along with quantification of glycogen in liver and in skeletal muscle and serum insulin level. We noted that after treatment of aqueous methanolic extract of above plant parts in separate as well as in composite manner at a concentration of 80mg/100g body weight/day to streptozotocin-induced diabetic rat resulted in a significant remedial effect on blood glucose level as well as carbohydrate metabolic enzymes and the quantity of liver and skeletal muscle glycogen. Serum insulin level that was diminished in streptozotocin-induced diabetic rat recovered significantly after the co-administration of extract of above plant parts. All the above parameters showed a more potent remedial effect after composite extract treatment with respect to separate treatment and none of the extract has any general metabolic toxicity induction.

Keywords
Diabetes, Glycaemic index, Insulin, Musa paradisiaca, Coccinia indica

 
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