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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 3, 2007, pp. 345-351
Bioline Code: tc07040
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 3, 2007, pp. 345-351

 en APOPTOSIS INDUCING EFFECT OF ANDROGRAPHOLIDE ON TD-47 HUMAN BREAST CANCER CELL LINE
Sukardiman, Harjotaruno; Widyawaruyanti, Aty; Sismindari & Zaini, Noor Cholies

Abstract

Andrographolide isolated from Andrographis paniculata check for this species in other resources Ness (Acanthaceae) at 0.35 mM , 0.70 mM and 1.40 mM induced DNA fragmentation and increased the percentage of apoptotic cells when TD-47 human breast cancer cell line was treated for 24 , 48 and 72 h. The results demonstrated that andrographolide can induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax , caspase-3 and decrease expression of bcl-2 determined by immunohistochemical analysis.

Keywords
Andrographis paniculata Ness , andrographolide, TD-47 cell , apoptosis

 
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