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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 4, No. 4, 2007, pp. 481 – 487
Bioline Code: tc07064
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 4, No. 4, 2007, pp. 481 – 487

 en ANTIMICROBIAL, WOUND HEALING AND ANTIOXIDANT ACTIVITIES OF ANTHOCEPHALUS CADAMBA check for this species in other resources
Prahalad Umachigi, Sanjay; Kumar, G. S; Jayaveera, K.N; Kishore kumar, D.V; Ashok kumar, C.K & Dhanapal, R

Abstract

Anthocephalus cadamba (Roxb.) Miq. Syn A. chinensis (Lamk) A. Rich (Rubiaceae) is ethnomedicinally widely used in the form of paste by tribe in western Ghats for treating skin diseases. In this context, antimicrobial potential of A. cadamba against a wide range of microorganisms was studied. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied, besides antioxidant activity to understand the mechanism of wound healing. The alchoholic and aqueous extract of this plant showed significant antibacterial and antifungal activity against almost all the organisms: Micrococcus luteus check for this species in other resources , Bacillus subtilis check for this species in other resources , Staphylococcus aureus check for this species in other resources , Escherichia coli check for this species in other resources , Klebsiella pneumoniae check for this species in other resources , Proteus mirabilis check for this species in other resources , Pseudomonas aeruginosa check for this species in other resources , and four fungi Candida albicans check for this species in other resources , Trichophyton rubrum check for this species in other resources - dermatophyte fungi, Aspergillus niger check for this species in other resources , Aspergillus flavus check for this species in other resources and Aspergillus nidulans check for this species in other resources - systemic fungi, with especially good activity against the dermatophyte (Trichophyton rubrum) and some infectious bacteria (Escherichia coli, Proteus mirabilis and Staphylococcus aureus) with an MIC of 2.5 μg/disc. The results show that A. cadamba extract has potent wound healing capacity as shown from the wound contraction and increased tensile strength. The results also indicated that A. cadamba extract possesses potent antioxidant activity by inhibiting lipid peroxidation and increase in the superoxide dismutase (SOD) and catalase activity.

Keywords
Anthocephalus cadamba; Antimicrobial activity; Antioxidant; Wound healing;

 
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