African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 5, No. 1, 2008, pp. 61-73
Bioline Code: tc08011
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 5, No. 1, 2008, pp. 61-73
© Copyright 2008 - African Journal Traditional, Complementary and Alternative Medicines
IN VITRO ANTIOXIDANT ACTIVITIES OF THE FRACTIONS OF COCCINIA GRANDIS L. LEAF EXTRACT|
Umamaheswari, M. & Chatterjee, T. K.
The present study was aimed at investigating the antioxidant activities of the various fractions of the hydromethanolic extract of the leaves of Coccinia grandis L. Voigt. (Cucurbitaceae). The antioxidant activities of the fractions have been evaluated by using nine in vitro assays and were compared to standard antioxidants such as ascorbic acid, α-tocopherol, curcumin and butylated hydroxyl toluene (BHT). All the fractions showed effective Hdonor activity, reducing power, free radical scavenging activity, metal chelating ability and inhibition of β-carotene bleaching. None of the fractions exerted an obvious pro-oxidant activity. The antioxidant property depends upon concentration and increased with increasing amount of the fractions. The free radical scavenging and antioxidant activities may be attributed to the presence of phenolic and flavonoid compounds present in the fractions. The results obtained in the present study indicate that the leaves of C. grandis are a potential source of natural antioxidant.
Coccinia grandis (Cucurbitaceae), free radicals, antioxidant, pro-oxidant.
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