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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 5, No. 4, 2008, pp. 394-398
Bioline Code: tc08055
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 5, No. 4, 2008, pp. 394-398

 en Toxicity and Immunomodulatory Activity of Fractions of Hibiscus Sabdariffa check for this species in other resources Linn (Family Malvaceae) in Animal Models
Fakeye, Titilayo

Abstract

This study evaluated immunomodulatory properties and the sub-acute toxicity profile of two fractions of the aqueousalcoholic extract of the dried calyx of Hibiscus Sabdariffa check for this species in other resources in experimental animals. Immunomodulatory activity was evaluated using red blood cell-induced immunostimulation. The fractions were not found to be toxic after 7-day administration, though there was severe weight loss with the residual water-soluble fraction (RWSF) and weight gain with the ethyl acetate soluble fraction (EAC). The EAC exhibited a significant dose-dependent immunostimulation (p<0.05)higher than thatobserved for levamisole (positive control). The residual water-soluble fraction exhibited immunostimulatory activity at 100mg/kg body weight. The two fractions caused a significant reduction in production of tissue necrosis factor – alpha and an increase in interleukin 10 (IL-10).

Keywords
Hibiscus sabdariffa, plant extract and fractions, sub-acute toxicity, immuno-modulatory activity,cytokine production

 
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