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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 6, No. 1, 2009, pp. 78-86
Bioline Code: tc09011
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 6, No. 1, 2009, pp. 78-86

 en Effects Of Tephrosia purpurea check for this species in other resources Aqueous Seed Extract On Blood Glucose And Antioxidant Enzyme Activities In Streptozotocin Induced Diabetic Rats
Pavana, P; Sethupathy, S; Santha, K & Manoharan, S

Abstract

The aim of the present study was to evaluate the effects of aqueous seed extract of Tephrosia purpurea check for this species in other resources (TpASet) on blood glucose and antioxidant status in streptozotocin induced diabetic rats. Hyperglycemia associated with an altered hexokinase and glucose-6-phosphatase activities, elevated lipid peroxidation, disturbed enzymatic [Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] and non enzymatic [Glutathione, vitamin C and vitamin E] antioxidant status were observed in streptozotocin induced diabetic rats. Oral administration of "TpASet" at a dose of 600mg/kg body weight showed significant improvement in above mentioned parameters. Our results clearly indicate that "TpASet" has potent antihyperglycemic and antioxidant effects in streptozotocin-induced diabetic rats and therefore further studies are warranted to isolate and characterize the bioactive principles from "TpASet".

Keywords
Streptozotocin; Tephrosia purpurea; Antioxidants; Lipid peroxidation

 
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