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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 6, No. 2, 2009, pp. 112-117
Bioline Code: tc09015
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 6, No. 2, 2009, pp. 112-117

 en Antiproliferative Effect Of Alcoholic Extracts Of Some Gabonese Medicinal Plants On Human Colonic Cancer Cells
Line-Edwigea, Mengome; Raymond, Feuya Tchouya Guy; François, Eba & Edouard, Nsi-Emvo

Abstract

Extracts from Piptadeniastrum africanum check for this species in other resources Brenan (Mimosaceae), Petersianthus macrocarpus check for this species in other resources (Breauv) L. (Lecydaceae), Cissus debilis check for this species in other resources Planch (Vitaceae) and Dieffenbachia seguine check for this species in other resources Jacq. (Araceae) were tested in vitro for their antiproliferative activity on human colon cancer cell line (CaCo-2). The highest antiproliferative activities were obtained with the alcoholic extracts of the roots of Piptadeniastrum africanum (G-PAR), the leaves of Petersianthus macrocarpus (G-PMF) and the stem of Cissus debilis (G-CDL), with 50% inhibition concentrations (IC50) of 15 μg/ml, 17 μg/ml and 25 μg/ml respectively. Only one extract (leaves of Dieffenbachia seguine (G-DSF)) exhibited weak antiproliferative activity with 50% inhibition concentration (IC50) higher than 50 μg/ml.

Keywords
Cissus debilis; Dieffenbachia seguine; Petersianthus macrocarpus; Piptadeniastrum africanum; antiproliferative activity; CaCo-2 cells.

 
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