Extracts from
Piptadeniastrum africanum
Brenan (Mimosaceae),
Petersianthus macrocarpus
(Breauv)
L. (Lecydaceae),
Cissus debilis
Planch (Vitaceae) and
Dieffenbachia seguine
Jacq. (Araceae) were tested
in
vitro for their antiproliferative activity on human colon cancer cell line (CaCo-2). The highest antiproliferative activities were obtained with the alcoholic extracts of the roots of
Piptadeniastrum africanum (G-PAR), the leaves of
Petersianthus macrocarpus (G-PMF) and the stem of Cissus debilis (G-CDL), with 50% inhibition
concentrations (IC50) of 15 μg/ml, 17 μg/ml and 25 μg/ml respectively. Only one extract (leaves of
Dieffenbachia seguine (G-DSF)) exhibited weak antiproliferative activity with 50% inhibition concentration
(IC
50) higher than 50 μg/ml.
