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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 7, No. 3, 2010, pp. 207-213
Bioline Code: tc10029
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 7, No. 3, 2010, pp. 207-213

 en New Antitrypanosomal Tetranotriterpenoids From Azadirachta indica
Githua, Mercy; Hassanali, Ahmed; Keriko, Joseph; Murilla, Grace; Ndungu, Mary & Nyagah, Gathu

Abstract

Organic extracts of the leaves of Azadirachta indica A. Juss. yielded ten antitrypanosomal terpenoids. Three of these (1 - 3), are novel and are derivatives of nimbolide and nimbin. They were extracted from chloroform fraction of methanol extract. These compounds were found to exhibit strong antitrypanosomal activities against Trypanosoma brucei rhodesiense with MIC values ranging of 6.9, 15.6 and 7.8 μg/ml respectively and were more active than Cymerlarsan ( a standard drug), which had an MIC value of 187.5 μg/ml when tested against T. b. rhodesiense The structures were elucidated by spectroscopic methods including; NMR, MS, UV and IR.

Keywords
Meliaceae, limonoids, Trypanosoma brucei rhodesiense, Azadirachta indica, antitrypanosomal activity.

 
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