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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 8, No. 3, 2011, pp. 312-321
Bioline Code: tc11040
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 8, No. 3, 2011, pp. 312-321

 en Protective Effect Of Ssanghwa-Tang Fermented By Lactobacillus fermentum check for this species in other resources against Carbon Tetrachloride-Induced Acute Hepatotoxicity In Rats
Eum, Hyun-Ae; Lee, Ji-Hye; Yang, Min-Cheol; Shim, Ki Shuk; Lee, Jae-Hoon & Ma, Jin Yeul

Abstract

Ssanghwa-tang (SHT) is a traditional herbal medicine formula that has been used for the development of physical strength, relief of pain, and the reduction of fatigue. In this study, we fermented SHT with Lactobacillus fermentum check for this species in other resources (L. fermentum), Lactobacillus gasseri check for this species in other resources (L.gasseri), or Lactobacillus casei check for this species in other resources (L.casei) to investigate the hepatoprotective effects of SHT and fermented SHT with Lactobacillus check for this species in other resources on carbon tetrachloride (CCl4)-induced liver injury in rats. Rats were given CCl4 (1 ml/kg, 50% CCl4 in olive oil) intraperitoneally and either SHT or fermented SHTs (15 ml/kg) was administered 30 min before CCl4. At 24 hr after CCl4 injection, the levels of transaminases in the serum were markedly increased. These increases were significantly attenuated by either SHT + L. fermentum or SHT+ L.gasseri. However, SHT and SHT + L.casei showed slight suppression of the increase of transaminases. The liver histological changes were diminished by treatment with SHT + L. fermentum. Additionally, the potential hepatoprotective effect of fermented-SHTs correlated with the amount of unknown metabolite which is produced during fermentation process with L. fermentum, L.gasseri, or L.casei. Therefore, these results suggest that the hepatoprotective effect of SHT may be improved by fermentation with L. fermentum and the intestinal bacterial enzyme activities may likely play an important role in the pharmacological action of herbal medicines.

Keywords
Carbon tetrachloride, Fermentation, Herbal fomula, Lactobacillus, Ssanghwa-tang

 
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