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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 33, No. 3, 2012, pp. 337-342
Bioline Code: zr12050
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 33, No. 3, 2012, pp. 337-342

 en Animal models of human glioma: the progress of application and investigation
ZHU, Hui-Fang; ZHANG, Yuan-Xu & ZHAO, Xu-Dong

Abstract

The glioma accounts for half of the central nervous tumors, among which the glioblastoma multiforme (GBM) is one of the most aggressive and lethal brain tumors. The difficulties in glioma therapy indicate the need of appropriate animal models for preclinical studies. Benefiting from the development of molecular biology, genetics, and transgenic technology, variable animal models of glioma have been established. These animal models of human glioma are reviewed in this paper.

Keywords
Glioma; Animal model; Transgenic mice; Tumor stem cell

 
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