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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 38, No. 6, 2017, pp. 317-320
Bioline Code: zr17041
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 38, No. 6, 2017, pp. 317-320

 en Overview of the improvement of the ring-stage survival assay - a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum
Zhang, Jie; Feng, Guo-Hua; Zou, Chun-Yan; Su, Pin-Can; Liu, Huai-E & Yang, Zhao-Qing

Abstract

Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay, is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay and explore its limitations and potential applications.

Keywords
Malaria; Artemisinin; Resistant phenotype; Ring-stage survival assay; Improvement; Application

 
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