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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 38, No. 6, 2017, pp. 317-320
Bioline Code: zr17041
Full paper language: English
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 38, No. 6, 2017, pp. 317-320

 zh 一种用于检测恶性疟原虫青蒿素抗性的新型表型检测方法-环状体阶段生存测定法(RSA)及其改进的综述
Zhang, Jie; Feng, Guo-Hua; Zou, Chun-Yan; Su, Pin-Can; Liu, Huai-E & Yang, Zhao-Qing


恶性疟原虫对青蒿素的抗药性产生,严重影响了全球范围内以青蒿素为基础的联合疗法的显著疗效。因此,测定疟原虫对青蒿素类药物的抗性,对于防控至关重要。环状体阶段生存测定法(RSA),可以用于表征青蒿素抗性或青蒿素敏感性降低。在这里,我们综述了环状体阶段生存测定的方法及近年的研究进展,并探讨了其局限性和潜在的应用前景。


疟疾; 青蒿素; 抗性表型; 环状体阶段生存测定法; 研究进展; 应用前景

 
 en Overview of the improvement of the ring-stage survival assay - a novel phenotypic assay for the detection of artemisinin-resistant Plasmodium falciparum
Zhang, Jie; Feng, Guo-Hua; Zou, Chun-Yan; Su, Pin-Can; Liu, Huai-E & Yang, Zhao-Qing

Abstract

Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay, is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay and explore its limitations and potential applications.

Keywords
Malaria; Artemisinin; Resistant phenotype; Ring-stage survival assay; Improvement; Application

 
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