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The Journal of Health, Population and Nutrition
icddr,b
ISSN: 1606-0997
EISSN: 1606-0997
Vol. 24, No. 1, 2006, pp. 25-35
Bioline Code: hn06005
Full paper language: English
Document type: Research Article
Document available free of charge

The Journal of Health, Population and Nutrition, Vol. 24, No. 1, 2006, pp. 25-35

 en Aetiology of Diarrhoea in a Birth Cohort of Children Aged 0-2 Year(s) in Rural Mirzapur, Bangladesh
Hasan, Khundkar Z.; Pathela, Preeti; Alam, Korshed; Podder, Goutam; Faruque, Shah M.; Roy, Eliza; Haque, A. K. M. Fazlul; Haque, Rashidul; Albert, M. John; Siddique, Abul K. & Sack, R. Bradley

Abstract

The incidence of aetiology-specific diarrhoea and the pathogenicity of infectious agents in a birth cohort (n=252) in rural Bangladesh were determined. Stool specimens or rectal swabs were collected from diarrhoeal cases over two years and routinely on a monthly basis. Stool samples from children with diarrhoea were compared with stool samples from children without diarrhoea to calculate rates of isolation and pathogenicity of agents. In total, 1,750 stool specimens from diarrhoea patients and 5,679 stool specimens from children without diarrhoea were tested. An infectious agent was identified in 58% of the stool specimens from diarrhoea patients and 21.6% of the stool specimens from children without diarrhoea. The most commonly-isolated pathogens from all specimens were enterotoxigenic Escherichia coli check for this species in other resources (ETEC), enteroadherent E. coli, Shigella check for this species in other resources , Campylobacter jejuni check for this species in other resources , Giardia check for this species in other resources , and rotavirus. ETEC (ST and LT-ST toxin), enterotoxigenic Bacteroides fragilis check for this species in other resources , Shigella, and rotavirus were associated more with disease than with asymptomatic infections. Aetiology-specific infections were associated with acute episodes. The isolated enteropathogens were essentially the same as those found in other tropical rural settings. Enterotoxigenic B. fragilis was also identified as a pathogen. Ongoing vaccine efforts focusing on Shigella, rotavirus, and ETEC would be useful.

Keywords
Diarrhoea; Diarrhoea, Infantile; Enteropathogens; Pathogenicity; Community-based studies; Cohort studies; Bangladesh

 
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